Cell Injury and Cell Death

This MOOC gives an overview of the factors causing cell injury-chemical, physical, intrinsic to the cell. It discuss the variety of cell adaptations (physiological as well as pathological) to this injuries and the various types of cell death which cells could undergo in case of inability to adapt: programmed or non-programmed type of cell death: apoptosis, autophagy, necrosis, etc. and their plentiful subtypes. All of this cell death subtypes are discussed in great detail to their molecular mechanism. Specifically, accent has been made to the processes of apoptosis and autophagy. The latter is also discussed in light of its therapeutic and wellbeing modulatory potentials.







Contents

1. Cell Injury and Adaptation

This lecture is about the various causes that damage human organism and the types of adaptation that cells undergo in response to the intrinsic and environmental changes 

1.1. Cell Injury

1.2. Molecular Mechanisms of Cell Damage

1.3. Adaptation

2. Cell Death Part I: Programmed Cell Death

This lecture is about the various types of programmed cell death and their molecular mechanisms and staging

2.1. Programmed cell death introduction, types, molecular mechanisms, examples

2.2. Apoptosis

2.3. Other forms of programmed cell death

3. Cell Death Part II: Autophagy and Necrosis

3.1. Autophagy: types and molecular mechanism

3.2. Autophagy as a therapeutic target and tool for wellbeing

3.3. Necrosis

4. Final test

4.1. Final test

Authors

Doctor, Senior Research Associate Clinical and Movement Neurosciences, University College London